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ATP levels drop with age, most dramatically after age 60

Biodistribution and therapeutic effects in subcutaneous osteosarcoma mouse model The therapeutic properties of the nanoparticles were further studied inside an 143B tumor-bearing immunodeficient nude mouse model (Fig

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Notably, the acetylation-defective P53 mutant (P53 3KR) can indirectly inhibit the uptake of cysteine, decrease GSH production, and induce lipid ROS accumulation, leading to ferroptosis [67, 74]