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In healthy volunteers with low fecal butyrate concentrations, 7990% of ingested HAMSB is released and absorbed in the gastrointestinal tract, with 57.2% of the release occurring in the colon [140]

& Geisbert, T

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Astrocytes release TNF- through the NF-B signaling pathway and act synergistically with COX2 to promote inflammation (71), whereas microglia rapidly secrete TNF- following glutamate receptor activation, directly triggering neuronal death (72)